A key step towards the achievement of controlled nuclear fusion in magnetic confinement devices is the mitigation of turbulence. Turbulent tokamak plasmas are intrinsically multiscale systems. Microturbulence generates meso-scale zonal flows. Additionally, energetic particles drive Alfvénic modes (AM) unstable, on meso- or macro-scales, and zonal structures. In this work, we investigate the possible interaction of AMs and turbulence via the evolution of the equilibrium profiles. Turbulence is known to strongly depend on the gradients of the equilibrium profiles, for example plasma density and temperature. AMs can nonlinearly modify the equilibrium profiles [1, 2, 3], and therefore affect turbulence. Viceversa, with the same mechanism, turbulence can affect the AM dynamics. We present results obtained by means of global gyrokinetic simulations with the particle-in- cell code ORB5 [4]. In recent simulations with ORB5, AMs have been shown to carry substan- tial heat and particle fluxes [5, 6]. Here, we extend that analysis by showing how the profile modification due to those fluxes can affect turbulence. References [1] L. Chen and F. Zonca, Rev. Mod. Phys. 88, 015008 (2016) [2] M. V. Falessi and F. Zonca, Phys. Plasmas 26, 022305 (2019) [3] F. Zonca, L. Chen, M. V. Falessi and Z. Qiu, J. Phys. Conf. Ser. 1785, 012005 (2021) [4] E. Lanti, et al, Comp. Phys. Commun. 251, 107072 (2020) [5] A. Biancalani, A. Bottino, P. Lauber, A. Mishchenko and F. Vannini, J. Plasma Phys. 86, 825860301A (2020) [6] A. Biancalani, et al, Plasma Phys. Control. Fusion 63, 065009 (2021)